Check out the latest paper in Nature Genetics by Battaglia et al.
Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.
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Flavahan, Drier et al. publish in Nature how epigenetic alterations drive oncogenic programs in SDH-deficient GISTs
You can read the study in Nature
Filbin, Tirosh, Hovestadt et al. dissect oncogenic programs in H3K27M gliomas by scRNA-seq
“The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin et al. used a single-cell sequencing approach to study the oncogenic programs, genetics, and cellular hierarchies of H3K27M-glioma. Tumors were mainly composed of cells resembling oligodendrocyte precursor cells, whereas … Continued
Congratulations Dan Tarjan!
Congratulations to Dan on the successful defense of his PhD thesis!
Puram, Tirosh, Parikh, et al. publish new findings in head and neck squamous cell carcinoma
Puram, Tirosh, Parikh, et al. from the Bernstein and Regev labs have completed a detailed single cell transcriptomic analysis of matched primary tumor and metastatic lymph nodes in head and neck squamous cell carcinoma patients, defining the landscape of tumor heterogeneity. The research team has identified a subpopulation of malignant cells which express a partial … Continued