Happy Holidays
Happy Holidays from the Bernstein lab and friends!
News
Welcome Laura, Peter, and Will!
Laura joins us as the new Lab Manager. Peter joins us from John Dick’s lab at the University of Toronto. Will is coming to us from Jeremy Rich’s lab at the Cleveland Clinic. Welcome!
Single cell RNA-seq study of primary glioblastoma featured in the Boston Globe
Anoop Patel, Mario Suvà, Shawn Gillespie with Itay Tirosh from the Regev lab and co-authors have described in new detail tumor heterogeneity in primary glioblastoma. The study, published this week in Science, shows the diverse set of transcriptional profiles that are present in primary tumors. The Boston Globe featured the study and brings it to … Continued
Suvà et al. describe four transcription factors key to glioblastoma tumor propogation
Mario Suvà, Esther Rheinbay, Shawn Gillespie, and Anoop Patel from this lab and colleagues have discovered a set of key transcription factors underlying glioblastoma stem-like cells. From the Broad blog: Glioblastoma, the most common and most aggressive form of brain cancer in adults, remains effectively incurable. Evidence suggests that “stem-like” cells help drive this difficult-to-treat … Continued
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
Knoechel et al. reveal how some T cell leukemias can evade NOTCH1 inhibiting drugs in Nature Genetics. Read more at the Broad Institute blog.